ONCOMETABOLITE LACTATE ENHANCES BREAST CANCER PROGRESSION BY ORCHESTRATING HISTONE LACTYLATION-DEPENDENT C-MYC EXPRESSION

Oncometabolite lactate enhances breast cancer progression by orchestrating histone lactylation-dependent c-Myc expression

Due to the enhanced glycolytic rate, cancer cells generate lactate copiously, subsequently promoting the lactylation of histones.While previous studies have explored the impact of histone lactylation in modulating gene expression, the precise role of this epigenetic modification in regulating oncogenes is largely unchartered.In this study, using br

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Regulation of COP1 Function by Brassinosteroid Signaling

Small dove dark chocolate squares increases in temperature result in enhanced elongation of the hypocotyl and petioles and hyponastic growth, in an adaptive response directed to the cooling of the leaves and to protect the shoot meristem from the warm soil.This response, collectively termed as thermomorphogenesis, relies on the faster reversion of

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Edge of Chaos in Memristor Cellular Nonlinear Networks

Information processing in the brain takes place in a dense network of neurons connected through synapses.The collaborative work between these two components (Synapses and Neurons) allows for basic brain functions such as learning and memorization.The so-called von Neumann bottleneck, which limits the information processing capability of conventiona

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